Endocrine Abstracts

Background: Insulin-like growth factor 1 (IGF1) has molecular structure similar to insulin. As an important mediator of growth hormone, IGF-1 plays roles in growth of children and anabolic effects of adults. We evaluate serum levels of IGF-1 in patients with hyperthyroidism or euthyroidism.Subjects and methods: In this study, 30 patients with hyperthyroidism (HY group) and 30 euthyroid individuals (EU group) were recruited. The patients of HY group were ...

Introduction: Phosphatase and tensin homolog gene (PTEN) gene encodes a lipid phosphatase that plays a central role in cell-cycle processes. PTEN hamartoma tumour syndrome (PHTS), caused by the mutation of the PTEN gene, is a diverse multi-system disorder. PHTS is characterised by the hamartomatous growths, increased risk of breast, thyroid, and renal cancers. In terms of thyroid presentation of PHTS, there is up to 75% risk of multinodular goitre and the life...

A 65-year-old female with PTEN Hamartoma Tumour Syndrome, Follicular thyroid carcinoma, and Endometrial Carcinoma, presented at a tertiary centre due to an asymptomatic adrenal lesion. Previous genetic testing for phaeochromocytoma and paraganglioma in 2020 showed no pathogenic variants in multiple genes (FH, MAX, MEN1, SDHx, SDHAF2, TMEM127, VHL, RET gene). Recent imaging revealed a 9 cm left supra-renal lesion that had been gradually increasing in size since 2010. Plasma nor...